Pombe) retroviral-like elements Tf1 Tf2 Murine Leukemia Virus (MLV) HIV Drosophila P-factors Drosophila P-factors R1 and R2 LINE element retrotransposons Localized, directional gene conversion (HO endonuclease cleavage initiates homology-dependent recombination)  Cleavage at specific recombination signal sequences (RSSs); flexible joining by nonhomologous end joining (NHEJ) functions (recognition of RSSs option nifty trading strategies RAG12 transposase) [5,58] 5 exons of immunoglobulin determinants (transcriptional specificity)  Lymphokine-controlled choice of switch regions (promoter activation)  Strong preference for insertion upstream of RNA polymerase III initiation sites (proteinprotein interaction tracing integrase with RNA polymerase III factors) [71,72] Preference for insertion upstream of RNA polymerase II initiation sites rather than exons  Strong preference for insertion in transcriptionally silenced regions of the strategirs genome (proteinprotein interaction of integrase with Sir4 silencing protein)  Insertion almost exclusively in intergenic regions (98 for Tf1); biased towards PolII promoter-proximal sites, 100400 bp upstream of the translation start; preference for chromosome 3  Preference for insertion upstream of transcription start sites in human genome [80,81] Preference for insertion into actively transcribed regions of human genome  Preference for insertion into the 5 end of transcripts  Targeting (homing) to regions of transcription factor function by incorporation of cognate binding site; region-specific  Insertion in arthropod ribosomal 28S coding sequences (sequence-specific endonuclease, reverse transcription) [87,88] Table continues on next page Event-Related Desynchronization and Synchronization 107 of nfity the areas of significant energy changes.
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